Motif ID: FOS_FOS{B,L1}_JUN{B,D}.p2

Z-value: 3.358


Transcription factors associated with FOS_FOS{B,L1}_JUN{B,D}.p2:

Gene SymbolEntrez IDGene Name
FOS 2353 v-fos FBJ murine osteosarcoma viral oncogene homolog
FOSB 2354 FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 8061 FOS-like antigen 1
JUNB 3726 jun B proto-oncogene
JUND 3727 jun D proto-oncogene

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
JUNDchr19_-_18253048-0.523.7e-02Click!
FOSchr14_+_748152330.448.6e-02Click!
JUNBchr19_+_12763295-0.263.2e-01Click!
FOSBchr19_+_50663089-0.224.0e-01Click!
FOSL1chr11_-_654243850.136.3e-01Click!


Activity profile for motif FOS_FOS{B,L1}_JUN{B,D}.p2.

activity profile for motif FOS_FOS{B,L1}_JUN{B,D}.p2


Sorted Z-values histogram for motif FOS_FOS{B,L1}_JUN{B,D}.p2

Sorted Z-values for motif FOS_FOS{B,L1}_JUN{B,D}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOS_FOS{B,L1}_JUN{B,D}.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_+_116099648 9.446 NM_000245
NM_001127500
MET

met proto-oncogene (hepatocyte growth factor receptor)

chr7_-_135083906 7.197 NM_205855
FAM180A
family with sequence similarity 180, member A
chr16_+_56219802 6.917 NM_001145771
NM_001145772
NM_001145773
NM_201524
NM_201525
GPR56




G protein-coupled receptor 56




chr19_-_40711034 6.686 NM_001166034
NM_001166035
NM_198538
SBSN


suprabasin


chr5_+_150000394 6.429 NM_001109974
NM_007286
SYNPO

synaptopodin

chr1_+_17719405 6.332 ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr1_+_181421984 6.099 LAMC2
laminin, gamma 2
chr6_+_31190505 5.860 NM_014068
PSORS1C1
psoriasis susceptibility 1 candidate 1
chr1_-_94779727 5.505 NM_001178096
NM_001993
F3

coagulation factor III (thromboplastin, tissue factor)

chr2_+_169634330 5.384 DHRS9
dehydrogenase/reductase (SDR family) member 9
chr12_-_68369322 5.320 NM_152439
BEST3
bestrophin 3
chr6_-_138470160 5.153 NM_022121
PERP
PERP, TP53 apoptosis effector
chr1_+_245646080 4.931 NM_001079821
NM_001127461
NLRP3

NLR family, pyrin domain containing 3

chr4_+_154397975 4.654 TRIM2
tripartite motif containing 2
chr17_-_36469869 4.497 NM_001165252
LOC730755
keratin associated protein 2-4-like
chr4_+_169989680 4.462 NM_001166110
PALLD
palladin, cytoskeletal associated protein
chr17_-_37022465 4.440 NM_005557
KRT16
keratin 16
chr4_+_108965167 4.423 NM_001136258
SGMS2
sphingomyelin synthase 2
chr5_+_140848905 4.257 NM_018929
NM_032407
PCDHGC5

protocadherin gamma subfamily C, 5

chr4_+_120276386 4.253 NM_016599
MYOZ2
myozenin 2
chr1_+_181421796 4.150 NM_005562
NM_018891
LAMC2

laminin, gamma 2

chr11_-_101906640 4.092 NM_002423
MMP7
matrix metallopeptidase 7 (matrilysin, uterine)
chr1_+_181422016 3.984 LAMC2
laminin, gamma 2
chr19_-_60573552 3.961 NM_000641
IL11
interleukin 11
chr16_+_70117523 3.903 NM_005769
NM_001166395
CHST4

carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4

chr1_+_221955876 3.895 NM_001146068
CAPN2
calpain 2, (m/II) large subunit
chr6_+_47732181 3.837 NM_153839
GPR111
G protein-coupled receptor 111
chr17_+_75776193 3.820 NM_052819
CARD14
caspase recruitment domain family, member 14
chr17_-_7962531 3.808 NM_021628
ALOXE3
arachidonate lipoxygenase 3
chr8_-_38505331 3.763 NM_207412
C8orf86
chromosome 8 open reading frame 86
chr2_+_202379442 3.655 NM_139158
CDK15
cyclin-dependent kinase 15
chr1_+_12698704 3.578 NM_001103169
NM_001103170
AADACL3

arylacetamide deacetylase-like 3

chr3_+_11153778 3.553 NM_001098213
HRH1
histamine receptor H1
chr11_+_72660894 3.472 NM_004154
P2RY6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr1_+_34997928 3.420 NM_153212
GJB4
gap junction protein, beta 4, 30.3kDa
chr9_-_90456824 3.386 NM_001100111
LOC286238
hypothetical protein LOC286238
chr13_-_35327798 3.348 NM_001195415
NM_001195416
NM_001195430
DCLK1


doublecortin-like kinase 1


chr12_-_51173238 3.279 NM_005554
KRT6A
keratin 6A
chr3_+_30622905 3.263 NM_001024847
NM_003242
TGFBR2

transforming growth factor, beta receptor II (70/80kDa)

chr12_-_51912101 3.262 NM_000966
RARG
retinoic acid receptor, gamma
chr6_-_169392771 3.159


chr4_+_76700281 3.155 NM_178497
C4orf26
chromosome 4 open reading frame 26
chr10_-_21847126 3.089


chr22_+_19699441 3.080 NM_001159554
NM_005446
P2RX6

purinergic receptor P2X, ligand-gated ion channel, 6

chr11_-_8695974 3.068 ST5
suppression of tumorigenicity 5
chr21_+_29439768 3.057 C21orf7
chromosome 21 open reading frame 7
chr22_+_21370394 3.044 IGL@
immunoglobulin lambda locus
chr17_-_36996611 3.002 NM_000526
KRT14
keratin 14
chr6_+_47774247 2.981 NM_153838
GPR115
G protein-coupled receptor 115
chr1_-_33139425 2.967 NM_033504
TMEM54
transmembrane protein 54
chr10_-_31328426 2.953 NM_001143769
ZNF438
zinc finger protein 438
chr7_-_16811131 2.951 NM_006408
AGR2
anterior gradient homolog 2 (Xenopus laevis)
chr2_+_69055208 2.872 NM_019617
GKN1
gastrokine 1
chr6_+_12398514 2.861 NM_001168319
NM_001955
EDN1

endothelin 1

chr11_-_10546654 2.847 NM_006691
LYVE1
lymphatic vessel endothelial hyaluronan receptor 1
chr10_+_123862430 2.843 TACC2
transforming, acidic coiled-coil containing protein 2
chr11_+_101488380 2.795 NM_001195045
YAP1
Yes-associated protein 1
chr22_+_21393107 2.792 IGLJ3
immunoglobulin lambda joining 3
chr3_-_188936941 2.787 NM_001130845
BCL6
B-cell CLL/lymphoma 6
chr18_+_19947314 2.783 TTC39C
tetratricopeptide repeat domain 39C
chr3_-_31997738 2.771 OSBPL10
oxysterol binding protein-like 10
chr11_+_101423378 2.750 NM_001195005
NM_032930
C11orf70

chromosome 11 open reading frame 70

chr3_+_30623376 2.722 TGFBR2
transforming growth factor, beta receptor II (70/80kDa)
chr6_+_41712907 2.692 MDFI
MyoD family inhibitor
chr6_+_83129641 2.690 NM_006670
TPBG
trophoblast glycoprotein
chr8_+_22900863 2.687 NM_001160036
RHOBTB2
Rho-related BTB domain containing 2
chr22_+_21464980 2.683


chr1_+_24518501 2.672 NM_001195010
GRHL3
grainyhead-like 3 (Drosophila)
chr11_+_20005704 2.661 NAV2
neuron navigator 2
chr5_+_73145098 2.658 RGNEF
190 kDa guanine nucleotide exchange factor
chr11_-_117640407 2.646 NM_005797
NM_144765
MPZL2

myelin protein zero-like 2

chr5_+_145297490 2.630 SH3RF2
SH3 domain containing ring finger 2
chr18_+_18989786 2.593 NM_138375
CABLES1
Cdk5 and Abl enzyme substrate 1
chr5_-_141041982 2.557 NM_022481
ARAP3
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
chr5_-_141041933 2.531 ARAP3
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
chr12_-_102967828 2.444 GLT8D2
glycosyltransferase 8 domain containing 2
chr10_+_24795446 2.442 KIAA1217
KIAA1217
chr3_-_18441763 2.438 NM_001195470
NM_002971
SATB1

SATB homeobox 1

chr14_+_95792299 2.434 NM_000710
BDKRB1
bradykinin receptor B1
chr1_+_24518398 2.404 NM_198173
NM_198174
GRHL3

grainyhead-like 3 (Drosophila)

chrX_+_133198742 2.331 NM_001101357
CCDC160
coiled-coil domain containing 160
chr20_+_34206070 2.323 NM_012156
EPB41L1
erythrocyte membrane protein band 4.1-like 1
chr6_-_10527772 2.306 NM_001042425
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr19_-_56215084 2.302 NM_002776
NM_001077500
KLK10

kallikrein-related peptidase 10

chr22_+_21495273 2.290


chr15_-_72952648 2.287 NM_005697
SCAMP2
secretory carrier membrane protein 2
chr3_-_31998241 2.275 NM_001174060
NM_017784
OSBPL10

oxysterol binding protein-like 10

chr10_+_24795465 2.273 KIAA1217
KIAA1217
chr5_+_145296313 2.273 NM_152550
SH3RF2
SH3 domain containing ring finger 2
chr20_+_44070946 2.252 NM_004994
MMP9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
chr9_+_123369219 2.248 NM_032552
DAB2IP
DAB2 interacting protein
chr3_-_46582806 2.240 NM_024512
LRRC2
leucine rich repeat containing 2
chr3_+_31998269 2.234 NM_001137674
ZNF860
zinc finger protein 860
chr12_-_10215942 2.234 NM_001172632
NM_001172633
NM_002543
OLR1


oxidized low density lipoprotein (lectin-like) receptor 1


chr10_-_62002672 2.228 ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr11_-_6298284 2.214 NM_145040
PRKCDBP
protein kinase C, delta binding protein
chr2_+_33213111 2.205 NM_000627
NM_001166264
NM_001166265
NM_001166266
LTBP1



latent transforming growth factor beta binding protein 1



chr1_+_234372454 2.193 NM_003272
GPR137B
G protein-coupled receptor 137B
chr6_-_119137923 2.182 NM_001178035
C6orf204
chromosome 6 open reading frame 204
chr9_-_109291866 2.181 NM_004235
KLF4
Kruppel-like factor 4 (gut)
chr12_-_105057940 2.178 NM_014840
NUAK1
NUAK family, SNF1-like kinase, 1
chr9_-_116920232 2.176 NM_002160
TNC
tenascin C
chr11_+_35596310 2.174 NM_014344
FJX1
four jointed box 1 (Drosophila)
chr4_-_89299034 2.165 NM_004827
ABCG2
ATP-binding cassette, sub-family G (WHITE), member 2
chr8_-_27528215 2.156 NM_001831
CLU
clusterin
chr20_-_43410437 2.145 NM_002999
SDC4
syndecan 4
chr1_-_84237316 2.126 NM_024686
TTLL7
tubulin tyrosine ligase-like family, member 7
chr7_+_22733290 2.113 NM_000600
IL6
interleukin 6 (interferon, beta 2)
chr6_-_150388292 2.077 NM_130900
RAET1L
retinoic acid early transcript 1L
chr1_+_150753601 2.067 NM_019060
CRCT1
cysteine-rich C-terminal 1
chr9_+_137694988 2.059 NM_001001676
LCN9
lipocalin 9
chr6_+_144040751 2.049 NM_001100164
NM_001100165
PHACTR2

phosphatase and actin regulator 2

chr17_-_36928604 2.048 NM_002275
KRT15
keratin 15
chr4_+_40032146 2.041 NM_017581
CHRNA9
cholinergic receptor, nicotinic, alpha 9
chr2_+_121271336 2.035 NM_005270
GLI2
GLI family zinc finger 2
chr22_+_21053972 2.030


chr18_-_72336133 2.027 NM_014643
ZNF516
zinc finger protein 516
chr3_-_152517204 2.026 NM_023915
GPR87
G protein-coupled receptor 87
chr2_-_69033515 1.992 NM_182536
GKN2
gastrokine 2
chr1_+_34993234 1.972 NM_005268
GJB5
gap junction protein, beta 5, 31.1kDa
chr1_-_151280201 1.960 NM_006945
SPRR2D
small proline-rich protein 2D
chr5_+_36642424 1.954 SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr6_+_107066422 1.950 NM_001624
AIM1
absent in melanoma 1
chr5_-_137099361 1.947 KLHL3
kelch-like 3 (Drosophila)
chr19_-_56164628 1.946 NM_002774
KLK6
kallikrein-related peptidase 6
chr6_+_45404031 1.937 NM_001015051
NM_001024630
RUNX2

runt-related transcription factor 2

chr2_+_220200530 1.926 NM_005070
NM_201574
SLC4A3

solute carrier family 4, anion exchanger, member 3

chr8_-_27528105 1.924 CLU
clusterin
chr2_+_113591940 1.915 NM_000577
NM_173841
NM_173843
IL1RN


interleukin 1 receptor antagonist


chr14_+_62740878 1.894 NM_020663
RHOJ
ras homolog gene family, member J
chr5_+_36644187 1.870 NM_001166695
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr1_-_150398327 1.869 NM_001122965
RPTN
repetin
chr18_+_19706979 1.853 NM_000227
NM_001127718
LAMA3

laminin, alpha 3

chr9_+_676640 1.848


chr11_-_119499188 1.832 TRIM29
tripartite motif containing 29
chr11_-_2907169 1.829 NM_003311
PHLDA2
pleckstrin homology-like domain, family A, member 2
chr5_-_137099602 1.825 NM_017415
KLHL3
kelch-like 3 (Drosophila)
chr6_+_1556543 1.823 FOXC1
forkhead box C1
chr7_-_142816019 1.817 NM_005232
EPHA1
EPH receptor A1
chr22_+_20899155 1.809


chr11_-_117640166 1.808 MPZL2
myelin protein zero-like 2
chr7_-_107430566 1.794 NM_002291
LAMB1
laminin, beta 1
chr12_+_13240868 1.778 NM_001423
EMP1
epithelial membrane protein 1
chr1_+_24522116 1.775 NM_021180
GRHL3
grainyhead-like 3 (Drosophila)
chr1_-_7923464 1.752 NM_001561
TNFRSF9
tumor necrosis factor receptor superfamily, member 9
chr17_-_51155073 1.749 NM_018286
TMEM100
transmembrane protein 100
chr11_-_76676110 1.738 NM_182833
GDPD4
glycerophosphodiester phosphodiesterase domain containing 4
chr17_-_37034288 1.733 NM_000422
KRT17
keratin 17
chr6_+_106653429 1.728 NM_182907
PRDM1
PR domain containing 1, with ZNF domain
chr1_+_27591738 1.721 NM_005281
GPR3
G protein-coupled receptor 3
chr17_+_71229110 1.717 NM_000213
NM_001005731
ITGB4

integrin, beta 4

chr14_-_22658078 1.716 NM_001805
CEBPE
CCAAT/enhancer binding protein (C/EBP), epsilon
chr2_+_233605625 1.703 NM_005383
NEU2
sialidase 2 (cytosolic sialidase)
chr18_-_26996742 1.700 NM_004948
NM_024421
DSC1

desmocollin 1

chr15_+_99276982 1.698 NM_024652
LRRK1
leucine-rich repeat kinase 1
chr12_-_10173947 1.695 NM_022570
NM_197947
NM_197948
NM_197949
NM_197950
NM_197954
CLEC7A





C-type lectin domain family 7, member A





chr12_+_13240983 1.695 EMP1
epithelial membrane protein 1
chr1_+_151270301 1.689 NM_003125
SPRR1B
small proline-rich protein 1B
chr19_-_40684638 1.671 NM_001035516
DMKN
dermokine
chr12_+_52733927 1.660 NM_153633
HOXC4
HOXC6
homeobox C4
homeobox C6
chr8_-_68821131 1.659 NM_020361
CPA6
carboxypeptidase A6
chr5_-_54317102 1.652 NM_001135604
NM_007036
ESM1

endothelial cell-specific molecule 1

chr1_-_85816520 1.652 NM_001134445
DDAH1
dimethylarginine dimethylaminohydrolase 1
chr4_-_152366970 1.646 NM_001009555
NM_001128923
SH3D19

SH3 domain containing 19

chr12_+_13240987 1.641 EMP1
epithelial membrane protein 1
chr1_+_19842309 1.637 NM_182744
NBL1
neuroblastoma, suppression of tumorigenicity 1
chr14_-_104507862 1.636 AHNAK2
AHNAK nucleoprotein 2
chr19_-_48661563 1.627 NM_014400
LYPD3
LY6/PLAUR domain containing 3
chr17_-_36409632 1.625 NM_031959
KRTAP3-2
keratin associated protein 3-2
chr2_+_27573206 1.620 NM_001486
GCKR
glucokinase (hexokinase 4) regulator
chr2_+_173394560 1.618 NM_001100397
RAPGEF4
Rap guanine nucleotide exchange factor (GEF) 4
chr11_-_117640196 1.617 MPZL2
myelin protein zero-like 2
chr6_+_121798443 1.616 NM_000165
GJA1
gap junction protein, alpha 1, 43kDa
chr3_-_71857097 1.608 NM_001134651
EIF4E3
eukaryotic translation initiation factor 4E family member 3
chr2_+_135312655 1.604 NM_138326
ACMSD
aminocarboxymuconate semialdehyde decarboxylase
chr19_+_40895669 1.590 NM_014383
ZBTB32
zinc finger and BTB domain containing 32
chr18_+_50646616 1.588 NM_004163
RAB27B
RAB27B, member RAS oncogene family
chr1_+_103898844 1.577 NM_020978
AMY2B
amylase, alpha 2B (pancreatic)
chr17_+_55269974 1.575


chr1_-_17179694 1.567 NM_001135248
NM_002403
MFAP2

microfibrillar-associated protein 2

chr11_-_66898223 1.562 NM_001166212
CLCF1
cardiotrophin-like cytokine factor 1
chr16_+_4546491 1.561 NM_001145011
LOC342346
hypothetical protein LOC342346
chr16_+_88515917 1.558 NM_001197181
TUBB3
tubulin, beta 3
chr8_-_125252884 1.558 C8orf78
chromosome 8 open reading frame 78
chr17_+_46067114 1.555 NM_001144070
NM_003786
ABCC3

ATP-binding cassette, sub-family C (CFTR/MRP), member 3

chr19_-_56204615 1.547 NM_012315
KLK9
kallikrein-related peptidase 9
chr2_+_36777336 1.544 NM_001177969
NM_001177970
NM_001177971
NM_001177972
NM_053276
VIT




vitrin




chr6_-_31756119 1.542 NM_025262
LY6G5C
lymphocyte antigen 6 complex, locus G5C
chr1_-_221920023 1.541 NM_001143962
CAPN8
calpain 8
chr19_+_43572679 1.534 NM_001039616
NM_001042522
SPRED3

sprouty-related, EVH1 domain containing 3

chr9_+_131974506 1.532 NM_014286
NCS1
neuronal calcium sensor 1
chr14_-_22515725 1.528 JUB
jub, ajuba homolog (Xenopus laevis)
chr1_-_120112989 1.525 NM_001166107
NM_005518
HMGCS2

3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)

chr2_-_166359016 1.507 NM_004482
GALNT3
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)
chr1_+_35019376 1.499 NM_024009
GJB3
gap junction protein, beta 3, 31kDa
chr7_-_93357881 1.499 NM_006528
TFPI2
tissue factor pathway inhibitor 2
chr12_-_121224676 1.490 NM_001014336
IL31
interleukin 31
chr22_+_21042091 1.489 IGLV1-44
IGL@
immunoglobulin lambda variable 1-44
immunoglobulin lambda locus
chr1_+_85300580 1.480 NM_145172
WDR63
WD repeat domain 63
chr6_+_237033 1.462 NM_020185
DUSP22
dual specificity phosphatase 22

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.44 8.83e-04 GO:0008544 epidermis development
5.37 1.60e-03 GO:0032963 collagen metabolic process
5.01 3.90e-03 GO:0044259 multicellular organismal macromolecule metabolic process
5.96 4.34e-03 GO:0030574 collagen catabolic process
5.10 8.69e-03 GO:0044243 multicellular organismal catabolic process
2.52 2.52e-02 GO:0032496 response to lipopolysaccharide
1.35 2.73e-02 GO:0048513 organ development
4.17 3.59e-02 GO:0044236 multicellular organismal metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
6.56 5.44e-05 GO:0001533 cornified envelope
1.42 8.68e-04 GO:0005856 cytoskeleton
2.25 8.68e-03 GO:0005882 intermediate filament
2.08 2.43e-02 GO:0045111 intermediate filament cytoskeleton
1.29 2.80e-02 GO:0005576 extracellular region
1.42 3.39e-02 GO:0044421 extracellular region part

Nothing significant found in function category.